The 30-year-old recovered after enduring a hard start to his West Ham career, conceding 10 goals in his first three matches, although back-up stopper Adrian will take his place between the posts against Spurs.
'It's a massive game, ' Antonio added.
West Ham defender Jose Fonte said the players owed the fans a good performance.
Antonio last played at the national stadium in 2010 when he scored for former club Southampton in their 4-1 victory over Carlisle United in the EFL Trophy final.
Wet and cool weather in forecast The warm weather will continue through the beginning of the week before a cold front moves through on Tuesday . Temperatures will only reach into the lower 60s making it feel very cool outside during the rain.
"I think Brighton are everything at the minute that West Ham are not - they are organised, they work hard for each other", the 2006 Hammer of the Year told the Alan Brazil Sports Breakfast.
West Ham players have taken it upon themselves to turn their form around, holding a meeting at the training ground on Monday.
"But, off the back of that, then when you go onto the pitch you have got to want to do it for yourself as well, and do it for your teammates around you, if you are not really believing in the manager". Goals have been a problem for West Ham as they have managed just eight in nine games with Chicarito Hernandez being responsible for three. I'd love to do it again on Wednesday night!'
Despite what has happened, the West Ham board are keen to keep the Croatian at least until the end of the season so that he can see out his contract and they will reportedly use the next two fixtures which are against Spurs in the Carabao Cup and against Crystal Palace in the League to make a decision.
Sgt. La David Johnson's Widow: Trump's Phone Call 'Made Me Cry'
Wilson's account of the phone call was "100 percent correct", Johnson told George Stephanopoulos Monday on Good Morning America . White House Chief of Staff John Kelly defended Trump, indicating that making such a phone call was hard under any circumstances.
Grizzlies maul Warriors, Cavs lose to Magic
Curry hit a fan when he first threw the guard in the 2016 NBA Finals, and no suspension came down for that issue. The two-time MVP appeared to be angry that the official didn't call a foul on his lay-up attempt.